Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR91 | A4D1P6 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17872726 | 1.00 | WDR91 (0.41) | WDR91PTGS2CCR2HDAC4HSD11B1 | |
| SCHEMBL17872779 | 0.85 | HDAC4 (0.41) | WDR91PTGS2CCR2HDAC4HSD11B1 | |
| SCHEMBL17872781 | 0.85 | HDAC4 (0.41) | WDR91PTGS2CCR2HDAC4HSD11B1 | |
| SCHEMBL15911420 | 0.83 | DGAT2 (0.38) | HSD11B1MAOAMAOBHDAC3HDAC1 | |
| SCHEMBL1560775 | 0.83 | DGAT2 (0.38) | HSD11B1MAOAMAOBHDAC3HDAC1 | |
| SCHEMBL15258671 | 0.82 | HDAC3 (0.47) | WDR91PTGS2CCR2HDAC4HSD11B1 | |
| SCHEMBL16161986 | 0.79 | HDAC4 (0.47) | WDR91CCR2HDAC4HSD11B1HDAC3 | |
| SCHEMBL2033871 | 0.74 | LIPG (0.41) | — | |
| SCHEMBL14541574 | 0.74 | TET3 (0.48) | PTGS2CCR2HDAC4HSD11B1MAOA | |
| SCHEMBL349710 | 0.74 | TET3 (0.48) | PTGS2CCR2HDAC4HSD11B1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3240784-A2 | INHIBITORS OF AKT KINASE | BerGenBio ASA (NO) | 2017-11-08 | — | — | EP | disclosed |
| WO-2016102672-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS | BERGENBIO AS (NO) | 2016-06-30 | — | — | WO | disclosed |