Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16162128 | 0.88 | BRAF (0.44) | BRAF | |
| SCHEMBL16162151 | 0.87 | CYP2D6 (0.43) | BRAFSLC40A1 | |
| SCHEMBL16162139 | 0.86 | BRAF (0.46) | BRAFSLC40A1 | |
| SCHEMBL16162113 | 0.86 | BRAF (0.48) | BRAFSLC40A1 | |
| SCHEMBL16162136 | 0.85 | CYP2C19 (0.40) | BRAF | |
| SCHEMBL287622 | 0.85 | BRAF (0.47) | BRAFSLC40A1JAK2JAK1TYK2 | |
| SCHEMBL16162106 | 0.85 | CYP3A4 (0.47) | BRAF | |
| SCHEMBL16161898 | 0.84 | CYP2C9 (0.46) | BRAF | |
| SCHEMBL16162152 | 0.82 | BRAF (0.47) | BRAF | |
| SCHEMBL16161908 | 0.82 | BRAF (0.45) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |