Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16166249 | 0.85 | NPC1 (0.83) | NPC1LMNAALDH1A1HTTRAB9A | |
| SCHEMBL16175844 | 0.83 | TSHR (0.56) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL16166354 | 0.81 | TSHR (0.53) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL16166275 | 0.81 | CYP19A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL16166191 | 0.81 | ALDH1A1 (0.76) | NPC1LMNAALDH1A1HTTRAB9A | |
| SCHEMBL4832108 | 0.79 | NPC1 (0.81) | NPC1LMNAALDH1A1HTTRAB9A | |
| SCHEMBL10513542 | 0.79 | NPC1 (0.70) | NPC1LMNAALDH1A1HTTRAB9A | |
| SCHEMBL19780049 | 0.78 | NPC1 (0.67) | NPC1LMNAALDH1A1HTTRAB9A | |
| SCHEMBL173434 | 0.77 | NPC1 (0.68) | NPC1LMNAALDH1A1HTTRAB9A | |
| SCHEMBL370942 | 0.76 | LMNA (0.80) | NPC1LMNAALDH1A1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |