Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16166184 | 0.88 | HTT (0.43) | ALOX5PTGESNFKB1STAT3NFKB2 | |
| SCHEMBL16166638 | 0.74 | ABCB1 (0.41) | ALOX5PTGESNFKB1STAT3NFKB2 | |
| SCHEMBL16166508 | 0.72 | AKR1C3 (0.41) | ALOX5PTGESNFKB1STAT3NFKB2 | |
| SCHEMBL13403399 | 0.72 | CYP3A4 (0.52) | CYP19A1MEN1KMT2ATDP1CYP3A4 | |
| SCHEMBL21798818 | 0.72 | TAAR1 (0.45) | MEN1KMT2ATDP1CYP3A4IMPDH2 | |
| SCHEMBL16166422 | 0.70 | TUBB1 (0.36) | ALOX5PTGESNFKB1STAT3NFKB2 | |
| SCHEMBL16166393 | 0.69 | ALOX5 (0.43) | ALOX5PTGESPPARGPTPN1MEN1 | |
| SCHEMBL11155846 | 0.69 | PTPN1 (0.48) | ALOX5PTGESNFKB1STAT3NFKB2 | |
| SCHEMBL4268956 | 0.67 | PTGS2 (0.41) | ALOX5PTGESNFKB1STAT3NFKB2 | |
| SCHEMBL3303362 | 0.67 | CYP19A1 (0.56) | ALOX5PTGESNFKB1STAT3NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2984072-A1 | SYNTHETIC ANALOGUES OF XANTHOHUMOL | Universita Di Pisa (IT) | 2016-02-17 | — | — | EP | disclosed |
| WO-2014167481-A1 | SYNTHETIC ANALOGUES OF XANTHOHUMOL | UNIVERSITA' DI PISA (IT) | 2014-10-16 | — | — | WO | disclosed |