Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.64 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.61 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.61 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | KIF11 | P52732 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16166749 | 0.87 | P2RX1 (0.61) | MAOBRXFP1P2RX1TMPRSS4MEN1 | |
| SCHEMBL18146433 | 0.86 | RORC (0.70) | MAOBRXFP1P2RX1TMPRSS4GRIK1 | |
| SCHEMBL5079427 | 0.82 | MAPT (0.71) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL8710692 | 0.82 | RXFP1 (0.81) | MAOBRXFP1GRIK1MEN1KMT2A | |
| SCHEMBL17103384 | 0.81 | RXFP1 (0.81) | RXFP1P2RX1MEN1KMT2AMAPT | |
| SCHEMBL5665824 | 0.80 | RXFP1 (0.88) | RXFP1P2RX1MEN1KMT2AOPRK1 | |
| SCHEMBL28330872 | 0.79 | RXFP1 (0.69) | MAOBRXFP1P2RX1GRIK1MEN1 | |
| SCHEMBL17103663 | 0.79 | MEN1 (0.75) | RXFP1GRIK1MEN1KMT2AMAPT | |
| SCHEMBL16166867 | 0.78 | P2RX1 (0.51) | P2RX1TMPRSS4MEN1KMT2AMAPT | |
| SCHEMBL6841093 | 0.78 | MEN1 (0.71) | P2RX1MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |