Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16166749 | 0.83 | P2RX1 (0.61) | P2RX1TMPRSS4PPARGPPARAMAPT | |
| SCHEMBL18146485 | 0.82 | MAPT (0.56) | P2RX1TMPRSS4PPARGPPARANR1I2 | |
| SCHEMBL16166595 | 0.78 | MAOB (0.64) | P2RX1TMPRSS4MAPTKMT2AMEN1 | |
| SCHEMBL5079427 | 0.76 | MAPT (0.71) | PPARGPPARAMAPTKMT2AMEN1 | |
| SCHEMBL3559340 | 0.73 | MAPT (0.50) | MAPTKMT2AMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL31665956 | 0.73 | MAPT (0.50) | MAPTKMT2AMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL1251751 | 0.73 | LMNA (0.48) | MAPTKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL18147725 | 0.72 | P2RX1 (0.56) | P2RX1TMPRSS4PPARGPPARAMAPT | |
| SCHEMBL7760831 | 0.72 | NPC1 (0.64) | PPARGPPARANR1I2CYP2C8PPARD | |
| SCHEMBL7762511 | 0.72 | NPC1 (0.64) | PPARGPPARANR1I2CYP2C8PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |