Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 4/20 | 0.61 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16166595 | 0.87 | MAOB (0.64) | P2RX1TMPRSS4MAPTKMT2AMEN1 | |
| SCHEMBL30868357 | 0.86 | P2RX1 (0.62) | P2RX1TMPRSS4SMN1; SMN2ABCG2MAPT | |
| SCHEMBL18146485 | 0.86 | MAPT (0.56) | P2RX1TMPRSS4SMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL18146911 | 0.85 | SMN1; SMN2 (0.71) | P2RX1TMPRSS4SMN1; SMN2ABCG2MAPT | |
| SCHEMBL16166867 | 0.83 | P2RX1 (0.51) | P2RX1TMPRSS4SMN1; SMN2ABCG2MAPT | |
| SCHEMBL5079427 | 0.83 | MAPT (0.71) | SMN1; SMN2MAPTCYP3A4MAPK1PPARG | |
| SCHEMBL13885092 | 0.80 | SMN1; SMN2 (0.68) | P2RX1TMPRSS4SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL11972898 | 0.80 | RAB9A (0.68) | ABCG2MAPTMAPK1KMT2AMEN1 | |
| SCHEMBL13428706 | 0.80 | RAB9A (0.68) | ABCG2MAPTMAPK1KMT2AMEN1 | |
| SCHEMBL28330879 | 0.78 | MEN1 (0.68) | SMN1; SMN2ABCG2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |