Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 2/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.38 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1618360 | 1.00 | PABPC1 (0.38) | PABPC1APOBEC3AAPOBEC3GEIF4HHTT | |
| SCHEMBL4899672 | 0.97 | LMNA (0.39) | PABPC1APOBEC3AAPOBEC3GEIF4HHTT | |
| Methyl Alcohol SCHEMBL6903083 | 0.90 | APOBEC3A (0.40) | PABPC1APOBEC3AAPOBEC3GEIF4HHTT | |
| SCHEMBL15282149 | 0.85 | CYP1A2 (0.35) | APOBEC3AAPOBEC3GHTTLMNAALDH1A1 | |
| SCHEMBL4893829 | 0.85 | CYP1A2 (0.35) | APOBEC3AAPOBEC3GHTTLMNAALDH1A1 | |
| SCHEMBL4907271 | 0.74 | ORAI1 (0.40) | ALDH1A1KMT2ACYP2C9SIGMAR1SLC6A2 | |
| SCHEMBL5944513 | 0.74 | APOBEC3A (0.40) | PABPC1APOBEC3AAPOBEC3GEIF4HHTT | |
| SCHEMBL2290692 | 0.74 | CYP1A2 (0.50) | APOBEC3AAPOBEC3GHTTLMNAALDH1A1 | |
| SCHEMBL76560 | 0.74 | LMNA (0.32) | PABPC1APOBEC3AAPOBEC3GEIF4HHTT | |
| SCHEMBL4432644 | 0.74 | CYP1A2 (0.35) | PABPC1APOBEC3AAPOBEC3GEIF4HHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160246-A1 | Neurodegenerative Protein Aggregation Inhibition Methods and Compounds | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2011-06-30 | — | — | US | disclosed |
| US-7923230-B2 | Diminishing presence of protein aggregates in an environment susceptible to formation of protein aggregate by introducing into environment a compound having two domains, a first domain that binds to protein aggregation having two monomers, and a second domain binding to diminishing protein | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-04-12 | — | — | US | disclosed |
| US-7485706-B2 | Neurodegenerative protein aggregation inhibition methods and compounds | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2009-02-03 | — | — | US | disclosed |
| US-20080182792-A1 | NEURODEGENERATIVE PROTEIN AGGREGATION INHIBITION METHODS AND COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-07-31 | — | — | US | disclosed |
| US-20050209173-A1 | Neurodegenerative protein aggregation inhibition methods and compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-09-22 | — | — | US | disclosed |
| WO-2005011610-A2 | NEURODEGENERATIVE PROTEIN AGGREGATION INHIBITION METHODS AND COMPOUNDS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2005-02-10 | — | — | WO | disclosed |