SCHEMBL16167207

SCHEMBL16167207

COc1ccccc1[Si](C)(Cl)C1c2cc(C(C)(C)C)ccc2-c2ccc(C(C)(C)C)cc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.34
ALDH1A1 P00352 3/20 0.34
NPC1 O15118 1/20 0.34
PLA2G1B P04054 1/20 0.34
NFKB1 P19838 1/20 0.34
CASP3 P42574 1/20 0.34
RAB9A P51151 1/20 0.34
NFKB2 Q00653 1/20 0.34
RELA Q04206 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
ATG4B Q9Y4P1 1/20 0.34
NPSR1 Q6W5P4 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
STK10 O94804 1/20 0.32
SLK Q9H2G2 1/20 0.32
HIF1A Q16665 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18684909 0.76 ALDH1A1 (0.33) MAPTALDH1A1NPC1PLA2G1BNFKB1
SCHEMBL6435462 0.74 ALDH1A1 (0.38) MAPTALDH1A1NPC1PLA2G1BNFKB1
SCHEMBL8373775 0.71 ALDH1A1 (0.44) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL44940 0.70 ALDH1A1 (0.40) MAPTALDH1A1NPC1PLA2G1BNFKB1
SCHEMBL16167343 0.70 CA1 (0.39) MAPTALDH1A1RAB9AL3MBTL1KMT2A
SCHEMBL5084054 0.67 CYP1A2 (0.37) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL4898057 0.67 HPGD (0.32) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL5090526 0.65 RAB9A (0.40) ALDH1A1NPC1RAB9AL3MBTL1MEN1
SCHEMBL5090372 0.65 CA1 (0.52) MAPTALDH1A1NPC1RAB9AL3MBTL1
SCHEMBL16167037 0.65 CA1 (0.52) MAPTALDH1A1NPC1RAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9611348-B2 Process of producing polyolefins using metallocene polymerization catalysts and copolymers therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2017-04-04 US disclosed
EP-2984111-A1 PROCESS OF PRODUCING POLYOLEFINS USING METALLOCENE POLYMERIZATION CATALYSTS AND COPOLYMERS THEREFROM ExxonMobil Chemical Patents Inc. (US) 2016-02-17 EP disclosed
US-20140316085-A1 Process of Producing Polyolefins Using Metallocene Polymerization Catalysts and Copolymers Therefrom EXXONMOBIL CHEMICAL PATENTS INC. 2014-10-23 US disclosed
WO-2014169017-A1 PROCESS OF PRODUCING POLYOLEFINS USING METALLOCENE POLYMERIZATION CATALYSTS AND COPOLYMERS THEREFROM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2014-10-16 WO disclosed