SCHEMBL6435462

SCHEMBL6435462

CC(C)(C)c1ccc2c(c1)C([Si](C)(C)Cl)c1cc(C(C)(C)C)ccc1-2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
PLA2G1B P04054 1/20 0.38
NFKB1 P19838 1/20 0.38
CASP3 P42574 1/20 0.38
NFKB2 Q00653 1/20 0.38
RELA Q04206 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ATG4B Q9Y4P1 1/20 0.38
HPGD P15428 2/20 0.35
ALOX15 P16050 1/20 0.35
HSD17B10 Q99714 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
ALOX5AP P20292 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6470599 0.85 ALDH1A1 (0.38) ALDH1A1NPC1RAB9APLA2G1BNFKB1
SCHEMBL44940 0.85 ALDH1A1 (0.40) ALDH1A1NPC1RAB9APLA2G1BNFKB1
SCHEMBL8373775 0.78 ALDH1A1 (0.44) ALDH1A1NPC1RAB9APLA2G1BNFKB1
SCHEMBL6432229 0.77 ALDH1A1 (0.35) ALDH1A1NPC1RAB9APLA2G1BNFKB1
SCHEMBL5084054 0.77 CYP1A2 (0.37) ALDH1A1NPC1RAB9APLA2G1BNFKB1
SCHEMBL30885499 0.76 ALDH1A1 (0.34) ALDH1A1NPC1RAB9APLA2G1BNFKB1
SCHEMBL6526472 0.75 ALDH1A1 (0.33) ALDH1A1NPC1RAB9APLA2G1BNFKB1
SCHEMBL18071854 0.75 CYP1A2 (0.35) ALDH1A1NPC1RAB9APLA2G1BNFKB1
SCHEMBL16167207 0.74 MAPT (0.34) ALDH1A1NPC1RAB9APLA2G1BNFKB1
SCHEMBL9754019 0.74 ALDH1A1 (0.44) ALDH1A1NPC1RAB9APLA2G1BNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1157046-B1 PROCESS FOR THE PREPARATION OF ETHYLENE POLYMERS BASELL POLYOLEFINE GMBH (DE) 2005-12-07 EP disclosed
US-6881493-B2 Polyolefins and uses thereof ATOFINA RESEARCH S.A. (BE) 2005-04-19 US disclosed
EP-1049741-B1 POLYOLEFIN COMPOSITIONS AND USES THEREOF TOTAL PETROCHEMICALS RES FELUY (BE) 2005-03-30 EP disclosed
US-6822106-B2 ADDITION POLYMERIZATION USING SILICON BRIDGED METALLOCENES HAVING TRICYCLIC CYCLOPENTADI(THIO)FURAN DERIVATIVE LIGANDS AS CATALYSTS BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2004-11-23 US disclosed
US-6787619-B2 UTILIZING SILICON BRIDGED METALLOCENES; HIGH MOLECULAR WEIGHT AND YIELD BASELL POLYOLEFINE GMBH (DE) 2004-09-07 US disclosed
US-20040097669-A1 Preparation of ethylene polymers BASELL POLYOLEFINE GMBH (DE) 2004-05-20 US disclosed
US-20030148877-A1 Metallocenes and catalysts for olefin-polymerisation BASELL TECHNOLOGY COMPANY BV (NL) 2003-08-07 US disclosed
US-20030036610-A1 Process for the preparation of ethylene polymers EQUISTAR CHEMICALS, LP 2003-02-20 US disclosed
EP-0952978-B1 METALLOCENES AND CATALYSTS FOR OLEFIN-POLYMERISATION BASELL POLYOLEFINE GMBH (DE) 2003-01-22 EP disclosed
US-6451724-B1 BIS(N-METHYL-5,10-DIHYDROINDENO(1,2-B)INDOL-10 -YL)TITANIUM DICHLORIDE BASELL TECHNOLOGY COMPANY BV (NL) 2002-09-17 US disclosed
WO-2001048040-A1 PROCESS FOR THE PREPARATION OF ETHYLENE POLYMERS BASELL TECHNOLOGY COMPANY B.V. (NL) 2001-07-05 WO disclosed
EP-0910591-B1 SYNDIOTACTIC/ATACTIC BLOCK POLYOLEFINS, CATALYSTS AND PROCESSES FOR PRODUCING THE SAME FINA RESEARCH (BE) 2001-03-21 EP disclosed
EP-0952978-A1 METALLOCENES AND CATALYSTS FOR OLEFIN-POLYMERISATION Montell Technology Company bv (NL) 1999-11-03 EP disclosed
EP-0931814-A1 Polyolefins and uses thereof FINA RESEARCH S.A. (BE) 1999-07-28 EP disclosed
WO-1999024446-A1 METALLOCENES AND CATALYSTS FOR OLEFIN-POLYMERISATION MONTELL TECHNOLOGY COMPANY B.V. (NL) 1999-05-20 WO disclosed
EP-0610843-B1 Process for preparing cyclo-olefin polymers TICONA GMBH (DE) 1999-05-19 EP disclosed
US-5733991-A POLYMERIZATION OF ETHYLENE WITH ALKYLENENORBORNENE IN THE PRESENCE OF ALUMINOXANE AND METALLOCENES HOECHST AKTIENGESELLSCHAFT (DE) 1998-03-31 US disclosed
EP-0818475-A1 Syndiotactic/atactic block polyolefins, catalysts and processes for producing the same FINA RESEARCH S.A. (BE) 1998-01-14 EP disclosed
CN-1096519-A The preparation method of cycloolefine polymer HOECHST AG (DE) 1994-12-21 CN disclosed
EP-0610843-A1 Process for preparing cyclo-olefin polymers HOECHST AKTIENGESELLSCHAFT (DE) 1994-08-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030148877-A1 Metallocenes and catalysts for olefin-polymerisation MT-CO1, CPNE4, MT-CO3 ALDH1A1 2373/4885NPC1 2068/4885RAB9A 2768/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.