Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.50 |
| ▸ | ITGAV | P06756 | 4/20 | 0.50 |
| ▸ | THRB | P10828 | 6/20 | 0.44 |
| ▸ | THRA | P10827 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 5/20 | 0.44 |
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852167 | 0.90 | ITGB3 (0.60) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL6852144 | 0.90 | ITGB3 (0.49) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL16167657 | 0.78 | THRB (0.53) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL25819213 | 0.77 | THRB (0.70) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL19695859 | 0.75 | THRB (0.58) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL24486433 | 0.75 | ITGB3 (0.57) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL19677580 | 0.73 | THRB (0.48) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL13949709 | 0.73 | THRB (0.77) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL19677576 | 0.73 | THRB (0.47) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL16167658 | 0.70 | THRB (0.44) | ITGB3ITGAVTHRBTHRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859539-B2 | Compositions of dual thyrointegrin antagonists and use in vascular-associated disorders | VASCULAR VISION PHARMACEUTICAL COMPANY (US) | 2014-10-14 | — | — | US | disclosed |