Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21230439 | 0.89 | GBA1 (0.39) | HRH1GRIN1GRIN2BLTA4HALDH1A1 | |
| SCHEMBL16065928 | 0.89 | HRH3 (0.40) | MEN1HRH3SIGMAR1TLR9TLR8 | |
| SCHEMBL13193523 | 0.89 | GBA1 (0.39) | HRH1GRIN1GRIN2BLTA4HALDH1A1 | |
| SCHEMBL25668002 | 0.89 | GBA1 (0.39) | HRH1GRIN1GRIN2BLTA4HALDH1A1 | |
| SCHEMBL23158168 | 0.86 | HRH2 (0.33) | HRH2HRH1HRH3SIGMAR1GRIN1 | |
| SCHEMBL12912029 | 0.83 | GNAI3 (0.42) | SIGMAR1HTR1A | |
| SCHEMBL14749186 | 0.83 | GNAI3 (0.42) | SIGMAR1HTR1A | |
| SCHEMBL14749169 | 0.83 | GNAI3 (0.42) | SIGMAR1HTR1A | |
| SCHEMBL23180450 | 0.83 | HRH3 (0.33) | HRH2HRH1HRH3SIGMAR1GRIN1 | |
| SCHEMBL23023302 | 0.83 | HRH2 (0.34) | HRH2HRH1HRH3SIGMAR1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187491-B2 | Gambogenic acid derivatives, preparation method and application thereof | NINTH PEOPLE'S HOSPITAL, SCHOOL MEDICINE SHANGHAI JIAO TONG UNIVERSITY (CN) | 2015-11-17 | — | — | US | disclosed |
| US-9187491-B2 | Gambogenic acid derivatives, preparation method and application thereof | NINTH PEOPLE'S HOSPITAL, SCHOOL MEDICINE SHANGHAI JIAO TONG UNIVERSITY (CN) | 2015-11-17 | — | — | US | disclosed |
| EP-2805956-A1 | GAMBOGENIC ACID DERIVATIVES, PREPARATION METHOD AND APPLICATION THEREOF | Ninth People's Hospital, School Medicine Shanghai Jiao Tong University (CN) | 2014-11-26 | — | — | EP | disclosed |
| US-20140309418-A1 | Gambogenic Acid Derivatives, Preparation Method and Application Thereof | NINTH PEOPLE'S HOSPITAL, SCHOOL MEDICINE SHANGHAI JIAO TONG UNIVERSITY (CN) | 2014-10-16 | — | — | US | disclosed |
| US-20140309418-A1 | Gambogenic Acid Derivatives, Preparation Method and Application Thereof | NINTH PEOPLE'S HOSPITAL, SCHOOL MEDICINE SHANGHAI JIAO TONG UNIVERSITY (CN) | 2014-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309418-A1 | Gambogenic Acid Derivatives, Preparation Method and Application Thereof | GYS2, GYPA, GLS2 | MEN1 976/4885HRH2 1939/4885HRH1 3828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.