Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5129896 | 0.98 | TRPM8 (0.51) | TRPM8FAAHKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL5125112 | 0.96 | TSHR (0.50) | TRPM8FAAHKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL16175730 | 0.95 | TRPM8 (0.49) | TRPM8FAAHSMN1; SMN2EPHX2TRPV1 | |
| SCHEMBL5119701 | 0.91 | FAAH (0.48) | TRPM8FAAHSMN1; SMN2TSHRCYP2C19 | |
| SCHEMBL5130354 | 0.90 | ALDH1A1 (0.54) | TRPM8FAAHSMN1; SMN2GAATSHR | |
| SCHEMBL5128806 | 0.90 | HPGD (0.48) | TRPM8KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5117044 | 0.90 | TRPM8 (0.52) | TRPM8SMN1; SMN2NPC1RAB9ATRPV1 | |
| SCHEMBL5128916 | 0.90 | TRPM8 (0.52) | TRPM8SMN1; SMN2NPC1RAB9ATRPV1 | |
| SCHEMBL16175638 | 0.89 | TRPV1 (0.52) | TRPM8EPHX2TRPV1TSHRCYP2C19 | |
| SCHEMBL5129811 | 0.88 | TRPV1 (0.47) | TRPM8SMN1; SMN2EPHX2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |