Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | PAK4 | O96013 | 2/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178749 | 0.88 | MAPK1 (0.43) | NTRK1PI4KBMAPTSMN1; SMN2HRH4 | |
| SCHEMBL16178736 | 0.88 | PI4KB (0.51) | NTRK1PI4KBMAPTHRH4SCN9A | |
| SCHEMBL16178784 | 0.79 | HRH4 (0.38) | NTRK1MAPTHRH4TP53MDM2 | |
| SCHEMBL16178781 | 0.79 | SMN1; SMN2 (0.48) | NTRK1MAPTSMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL16178773 | 0.76 | PI4KB (0.48) | NTRK1PI4KBSCN9ASCN10A | |
| SCHEMBL16178733 | 0.75 | PKM (0.64) | MAPTSMN1; SMN2L3MBTL1TP53LMNA | |
| SCHEMBL16178776 | 0.75 | NTRK1 (0.41) | NTRK1PI4KBSMN1; SMN2L3MBTL1HRH4 | |
| SCHEMBL16177994 | 0.75 | PI4KB (0.50) | PI4KBMAPTALDH1A1POLB | |
| SCHEMBL16178762 | 0.74 | SMN1; SMN2 (0.54) | NTRK1MAPTSMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL16178743 | 0.74 | REN (0.38) | NTRK1HRH4SCN9APAK4SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096614-B2 | Therapeutically active thiazolo-pyrimidine derivatives | UCB PHARMA SA (BE) | 2015-08-04 | — | — | US | disclosed |
| US-20140315885-A1 | Therapeutically Active Thiazolo-Pyrimidine Derivatives | UCB PHARMA SA (BE) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315885-A1 | Therapeutically Active Thiazolo-Pyrimidine Derivatives | TPMT, IFNG, IRF3 | NTRK1 3223/4885PI4KB 800/4885MAPT 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.