Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 12/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | ACP1 | P24666 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14473965 | 0.91 | ABCG2 (0.64) | AURKAAURKBMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL2155632 | 0.90 | ABCG2 (0.63) | AURKAAURKBMEN1KMT2AMAPT | |
| SCHEMBL16404461 | 0.84 | ABCG2 (0.74) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL12619236 | 0.83 | AURKA (0.86) | AURKAAURKBMEN1KMT2AMAPT | |
| SCHEMBL16183327 | 0.81 | ABCG2 (0.65) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL1062754 | 0.81 | ABCG2 (0.65) | AURKAAURKBMEN1KMT2AMAPT | |
| SCHEMBL16183247 | 0.79 | MAP4K2 (0.51) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL16183242 | 0.79 | ABCG2 (0.62) | AURKAAURKBMEN1KMT2AMAPT | |
| SCHEMBL14359237 | 0.79 | ABCG2 (0.62) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL16183323 | 0.79 | ABCG2 (0.62) | MEN1KMT2AMAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP2CA, PPP4C, PPP3CB | AURKA 2190/4885AURKB 1803/4885MEN1 4814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.