Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.48 |
| ▸ | MTOR | P42345 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14475253 | 0.92 | MAPT (0.48) | ALDH1A1HTTSMN1; SMN2GBA1GAA | |
| SCHEMBL16184051 | 0.92 | MAPT (0.46) | ALDH1A1HTTSMN1; SMN2GBA1GAA | |
| SCHEMBL16184810 | 0.91 | MAPT (0.50) | ALDH1A1HTTSMN1; SMN2GBA1GAA | |
| SCHEMBL16184730 | 0.91 | ALDH1A1 (0.53) | ALDH1A1HTTSMN1; SMN2GBA1PIK3CA | |
| SCHEMBL16184813 | 0.90 | CYP1A2 (0.52) | ALDH1A1HTTSMN1; SMN2GBA1GAA | |
| SCHEMBL16184713 | 0.90 | ALDH1A1 (0.52) | ALDH1A1HTTSMN1; SMN2GBA1PIK3CA | |
| SCHEMBL16184795 | 0.90 | ALDH1A1 (0.54) | ALDH1A1HTTSMN1; SMN2GBA1PIK3CA | |
| SCHEMBL16184777 | 0.88 | ALDH1A1 (0.50) | ALDH1A1HTTSMN1; SMN2GBA1PIK3CA | |
| SCHEMBL16184696 | 0.88 | ALDH1A1 (0.54) | ALDH1A1HTTSMN1; SMN2GBA1PIK3CA | |
| SCHEMBL14475243 | 0.87 | MAPT (0.43) | ALDH1A1SMN1; SMN2GAAMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP2CA, PPP4C, PPP3CB | ALDH1A1 1687/4885HTT 1176/4885SMN1; SMN2 3987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.