Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP4 | P55087 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16186399 | 0.88 | ABL1 (0.53) | RAB9AABCG2ABL1BCRSCN9A | |
| SCHEMBL16186309 | 0.85 | AQP4 (0.53) | AQP4RAB9AABCG2LMNACYP1A2 | |
| SCHEMBL16184419 | 0.83 | KMO (0.51) | ABCG2ABL1BCRLMNACYP1A2 | |
| SCHEMBL14358703 | 0.78 | ABCG2 (0.52) | RAB9AABCG2LMNACYP1A2CYP3A4 | |
| SCHEMBL16183623 | 0.78 | CYP1A2 (0.49) | RAB9AABCG2LMNACYP1A2CYP3A4 | |
| SCHEMBL16183564 | 0.77 | CYP1A2 (0.48) | RAB9AABCG2LMNACYP1A2CYP3A4 | |
| SCHEMBL16183618 | 0.77 | CYP1A2 (0.48) | RAB9AABCG2LMNACYP1A2CYP3A4 | |
| SCHEMBL16184845 | 0.76 | CYP1A2 (0.52) | RAB9AABCG2LMNACYP1A2CYP3A4 | |
| SCHEMBL16184451 | 0.76 | CYP1A2 (0.43) | RAB9AABCG2LMNASCN9ACYP1A2 | |
| SCHEMBL16186442 | 0.76 | ABCB1 (0.46) | ABCG2LMNACYP1A2CYP3A4GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP2CA, PPP4C, PPP3CB | AQP4 1628/4885RAB9A 1340/4885ABCG2 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.