Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.66 |
| ▸ | PORCN | Q9H237 | 4/20 | 0.66 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ADH5 | P11766 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16197934 | 0.79 | PORCN (1.00) | CYP2D6CYP3A4PORCNMEN1ALOX15 | |
| SCHEMBL16201504 | 0.78 | NPC1 (0.59) | CYP3A4MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5647696 | 0.76 | RAB9A (0.54) | CYP2D6CYP3A4PORCNPDE10AMEN1 | |
| SCHEMBL16201462 | 0.75 | PORCN (0.79) | CYP2D6CYP3A4PORCNMEN1ALOX15 | |
| SCHEMBL5648868 | 0.75 | PDE10A (0.55) | CYP2D6CYP3A4PORCNPDE10AMEN1 | |
| SCHEMBL16197793 | 0.75 | PORCN (0.74) | CYP2D6CYP3A4PORCNMEN1ALOX15 | |
| SCHEMBL16201303 | 0.74 | PORCN (0.78) | CYP2D6CYP3A4PORCNMEN1ALOX15 | |
| SCHEMBL16198312 | 0.74 | PORCN (0.84) | CYP2D6CYP3A4PORCNTSHRKMT2A | |
| Ether SCHEMBL6337288 | 0.74 | MEN1 (0.76) | CYP2D6CYP3A4PORCNMEN1ALOX15 | |
| SCHEMBL5649047 | 0.73 | CYP2D6 (0.52) | CYP2D6CYP3A4PORCNPDE10AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014175832-A1 | WNT PATHWAY MODULATORS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-10-30 | — | — | WO | disclosed |
| WO-2014175832-A1 | WNT PATHWAY MODULATORS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-10-30 | — | — | WO | disclosed |