Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 8/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | WNT3A | P56704 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ADH5 | P11766 | 1/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16198168 | 0.83 | PORCN (0.73) | PORCNCYP3A4CYP2D6WNT3AMEN1 | |
| SCHEMBL16197934 | 0.81 | PORCN (1.00) | PORCNCYP3A4CYP2D6WNT3AMEN1 | |
| SCHEMBL5773818 | 0.80 | PORCN (0.57) | PORCNCYP3A4CYP2D6WNT3AMEN1 | |
| SCHEMBL13356363 | 0.79 | MAPT (0.80) | MEN1TSHRKMT2ALMNASMN1; SMN2 | |
| SCHEMBL4530179 | 0.79 | LMNA (0.83) | MEN1TSHRKMT2ALMNARAB9A | |
| SCHEMBL28194557 | 0.77 | MAPT (0.66) | MEN1TSHRKMT2ALMNASMN1; SMN2 | |
| SCHEMBL6660795 | 0.76 | MEN1 (1.00) | PORCNCYP3A4CYP2D6WNT3AMEN1 | |
| SCHEMBL16198187 | 0.76 | PORCN (0.64) | PORCNCYP3A4CYP2D6WNT3AMEN1 | |
| SCHEMBL5772720 | 0.76 | PORCN (0.55) | PORCNCYP3A4CYP2D6WNT3AMEN1 | |
| SCHEMBL16198315 | 0.76 | PORCN (0.75) | PORCNCYP3A4CYP2D6WNT3AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014175832-A1 | WNT PATHWAY MODULATORS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-10-30 | — | — | WO | disclosed |
| WO-2014175832-A1 | WNT PATHWAY MODULATORS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-10-30 | — | — | WO | disclosed |