Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 8/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADH5 | P11766 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773818 | 0.94 | PORCN (0.57) | PORCNCYP3A4CYP2D6LMNATBXAS1 | |
| SCHEMBL16198151 | 0.76 | PORCN (0.71) | PORCNCYP3A4CYP2D6LMNATBXAS1 | |
| SCHEMBL5774790 | 0.75 | MAPT (0.64) | LMNAALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5773840 | 0.75 | MAPT (0.43) | LMNAALDH1A1RAB9ASMN1; SMN2ALOX15 | |
| SCHEMBL5773844 | 0.74 | HDAC3 (0.40) | LMNAALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5774078 | 0.74 | LTA4H (0.53) | LMNAALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5797999 | 0.74 | HDAC3 (0.40) | LMNAALDH1A1RAB9ASMN1; SMN2ALOX15 | |
| SCHEMBL5773983 | 0.73 | GLA (0.53) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5797994 | 0.73 | HDAC3 (0.39) | CYP3A4LMNAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5773366 | 0.73 | LTA4H (0.43) | LMNAALDH1A1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | PORCN 652/4885CYP3A4 39/4885CYP2D6 192/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | PORCN 2069/4885CYP3A4 76/4885CYP2D6 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.