Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20801631 | 0.88 | LMNA (0.50) | ALDH1A1MAPK1GAALMNAGLA | |
| SCHEMBL17520238 | 0.80 | LMNA (0.54) | ALDH1A1MAPK1GAALMNAGLA | |
| SCHEMBL20801636 | 0.78 | LMNA (0.49) | ALDH1A1MAPK1GAALMNAGLA | |
| SCHEMBL16198560 | 0.78 | LMNA (0.51) | ALDH1A1MAPK1GAALMNAGLA | |
| SCHEMBL16198462 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MAPK1GAALMNAGLA | |
| SCHEMBL20801630 | 0.77 | LMNA (0.50) | ALDH1A1MAPK1GAALMNAGLA | |
| SCHEMBL16198563 | 0.77 | LMNA (0.54) | ALDH1A1MAPK1GAALMNAGLA | |
| SCHEMBL16198294 | 0.75 | LMNA (0.49) | ALDH1A1MAPK1GAALMNAGLA | |
| SCHEMBL20801634 | 0.74 | LMNA (0.48) | ALDH1A1MAPK1GAALMNAGLA | |
| SCHEMBL18878409 | 0.74 | LMNA (0.54) | ALDH1A1MAPK1GAALMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2988742-A1 | THIAZOLES AND USES THEREOF | AbbVie Inc. (US) | 2016-03-02 | — | — | EP | claimed |
| WO-2014176268-A1 | THIAZOLES AND USES THEREOF | ABBVIE INC. (US) | 2014-10-30 | — | — | WO | claimed |
| EP-2988742-A1 | THIAZOLES AND USES THEREOF | AbbVie Inc. (US) | 2016-03-02 | — | — | EP | disclosed |
| WO-2014176268-A1 | THIAZOLES AND USES THEREOF | ABBVIE INC. (US) | 2014-10-30 | — | — | WO | disclosed |