Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16198294 | 0.91 | LMNA (0.49) | LMNAGLAALDH1A1MAPK1GAA | |
| SCHEMBL17520238 | 0.81 | LMNA (0.54) | LMNAGLAALDH1A1MAPK1GAA | |
| SCHEMBL20801631 | 0.80 | LMNA (0.50) | LMNAGLAALDH1A1MAPK1GAA | |
| SCHEMBL20801636 | 0.79 | LMNA (0.49) | LMNAGLAALDH1A1MAPK1GAA | |
| SCHEMBL16198293 | 0.78 | ALDH1A1 (0.48) | LMNAGLAALDH1A1MAPK1GAA | |
| SCHEMBL20801630 | 0.77 | LMNA (0.50) | LMNAGLAALDH1A1MAPK1GAA | |
| SCHEMBL16198563 | 0.77 | LMNA (0.54) | LMNAGLAALDH1A1MAPK1GAA | |
| SCHEMBL16198569 | 0.76 | LMNA (0.46) | LMNAGLAALDH1A1MAPK1GAA | |
| SCHEMBL16198106 | 0.75 | GPX4 (0.48) | ALDH1A1GAAKDM4EHSD17B10TAAR1 | |
| SCHEMBL20801634 | 0.75 | LMNA (0.48) | LMNAGLAALDH1A1MAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2988742-A1 | THIAZOLES AND USES THEREOF | AbbVie Inc. (US) | 2016-03-02 | — | — | EP | claimed |
| WO-2014176268-A1 | THIAZOLES AND USES THEREOF | ABBVIE INC. (US) | 2014-10-30 | — | — | WO | claimed |
| EP-2988742-A1 | THIAZOLES AND USES THEREOF | AbbVie Inc. (US) | 2016-03-02 | — | — | EP | disclosed |
| WO-2014176268-A1 | THIAZOLES AND USES THEREOF | ABBVIE INC. (US) | 2014-10-30 | — | — | WO | disclosed |