Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977811 | 0.83 | LPL (0.33) | GSK3B | |
| SCHEMBL9940899 | 0.77 | KDM4E (0.32) | HPGDHTTHSD17B10EGFR | |
| SCHEMBL16152935 | 0.75 | HPGD (0.35) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL14788359 | 0.71 | SPR (0.46) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL14883750 | 0.70 | SPR (0.39) | GSK3BEGFR | |
| SCHEMBL20689258 | 0.70 | TYK2 (0.33) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL3198883 | 0.70 | IDO1 (0.33) | EGFR | |
| SCHEMBL30895241 | 0.69 | GSK3B (0.37) | GSK3BEGFR | |
| SCHEMBL16199065 | 0.69 | HPGD (0.46) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL30731155 | 0.69 | HSD17B10 (0.42) | HPGDHTTHSD17B10MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871774-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-28 | — | — | US | disclosed |