Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14788359 | 0.80 | SPR (0.46) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL30731155 | 0.79 | HSD17B10 (0.42) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL22553976 | 0.79 | HSD17B10 (0.42) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL31167133 | 0.79 | GSK3B (0.58) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL12703712 | 0.79 | HSD17B10 (0.46) | HTTHSD17B10KMT2AGSK3BALDH1A1 | |
| SCHEMBL19230910 | 0.79 | SPR (0.36) | GSK3BALDH1A1SPRPOLB | |
| SCHEMBL3026539 | 0.79 | GSK3B (0.43) | GSK3BALDH1A1SPRPOLB | |
| SCHEMBL18538040 | 0.76 | HPGD (0.40) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL13237216 | 0.75 | ALDH1A1 (0.35) | GSK3BALDH1A1SPRPOLB | |
| SCHEMBL27714790 | 0.72 | HPGD (0.38) | HPGDHTTHSD17B10MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871774-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-28 | — | — | US | disclosed |