Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | CASP1 | P29466 | 3/20 | 0.50 |
| ▸ | CASP7 | P55210 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16199562 | 0.94 | MAPK1 (0.47) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL31633231 | 0.79 | MAPT (0.45) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL9235864 | 0.73 | NPC1 (0.44) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL16917441 | 0.72 | HTT (0.41) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL16199533 | 0.71 | MAPT (0.47) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL16252949 | 0.71 | MAPT (0.39) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL1855065 | 0.69 | NPC1 (0.41) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL21561012 | 0.69 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL21561026 | 0.69 | MAPK1 (0.57) | ALDH1A1HPGDKDM4EHSD17B10CASP1 | |
| SCHEMBL16199530 | 0.69 | MAPT (0.60) | ALDH1A1HPGDMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140343283-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2014-11-20 | — | — | US | disclosed |
| US-20140343283-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2014-11-20 | — | — | US | disclosed |
| EP-2796461-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | Beta Pharmaceuticals Co., Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343283-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | ABL1, JAK2, ALK | ALDH1A1 2825/4885HPGD 4001/4885KDM4E 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.