Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 3/20 | 0.34 |
| ▸ | RET | P07949 | 12/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904437 | 0.88 | CKS1B (0.37) | PIM1PIM2FLT3 | |
| SCHEMBL9904710 | 0.82 | ALOX5AP (0.39) | PIM1PIM2RORCFLT3 | |
| SCHEMBL15446264 | 0.76 | PIM1 (0.39) | PIM1PIM2 | |
| SCHEMBL9904379 | 0.76 | PIM1 (0.39) | PIM1PIM2 | |
| SCHEMBL9942514 | 0.76 | PIM1 (0.39) | PIM1PIM2 | |
| SCHEMBL9904681 | 0.68 | CKS1B (0.40) | PIM1PIM2RORC | |
| SCHEMBL9904776 | 0.67 | CKS1B (0.42) | PIM1PIM2 | |
| SCHEMBL9904243 | 0.67 | CKS1B (0.38) | RAF1BRAF | |
| SCHEMBL9904294 | 0.66 | L3MBTL1 (0.40) | KMO | |
| SCHEMBL12616111 | 0.65 | PTGS2 (0.40) | PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2796456-A1 | Bicyclic compounds as Pim inhibitors | Amgen Inc. (US) | 2014-10-29 | — | — | EP | disclosed |