Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | IDH1 | O75874 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683020 | 0.75 | PRMT6 (0.43) | PRMT6NPC1MAPTIDH1RAB9A | |
| SCHEMBL30552852 | 0.71 | NPC1 (0.39) | PRMT6NPC1MAPTIDH1RAB9A | |
| SCHEMBL1922123 | 0.68 | PRMT6 (0.45) | PRMT6NPC1MAPTIDH1RAB9A | |
| SCHEMBL16200114 | 0.67 | ADORA2A (0.44) | NPC1MAPTGAAKDM4E | |
| SCHEMBL535692 | 0.67 | KDM4E (0.40) | PRMT6NPC1MAPTRAB9ANPSR1 | |
| SCHEMBL8259527 | 0.66 | NPC1 (0.58) | PRMT6NPC1MAPTIDH1RAB9A | |
| SCHEMBL31364581 | 0.66 | MAPT (0.54) | PRMT6NPC1MAPTRAB9ANPSR1 | |
| SCHEMBL16574212 | 0.66 | MAPT (0.43) | PRMT6NPC1MAPTIDH1RAB9A | |
| SCHEMBL6180318 | 0.66 | PRMT6 (0.46) | PRMT6NPC1MAPTIDH1RAB9A | |
| SCHEMBL30834464 | 0.65 | PRMT6 (0.39) | PRMT6NPC1MAPTIDH1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |