Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | IDH1 | O75874 | 5/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683025 | 0.79 | RAB9A (0.42) | MAPTNPC1NPSR1RAB9AHTT | |
| SCHEMBL16200112 | 0.75 | PRMT6 (0.42) | PRMT6MAPTNPC1IDH1IDH2 | |
| SCHEMBL16200338 | 0.74 | POLB (0.34) | MAPTNPC1RAB9AHTTPOLB | |
| SCHEMBL13683141 | 0.73 | ALDH1A1 (0.32) | POLB | |
| SCHEMBL13683019 | 0.68 | NOTUM (0.43) | POLB | |
| SCHEMBL13683028 | 0.68 | ADORA2A (0.44) | MAPTNPC1POLBKDM4E | |
| SCHEMBL535692 | 0.68 | KDM4E (0.40) | PRMT6MAPTNPC1NPSR1RAB9A | |
| SCHEMBL8259527 | 0.67 | NPC1 (0.58) | PRMT6MAPTNPC1IDH1IDH2 | |
| SCHEMBL31364581 | 0.67 | MAPT (0.54) | PRMT6MAPTNPC1NPSR1RAB9A | |
| SCHEMBL16574212 | 0.67 | MAPT (0.43) | PRMT6MAPTNPC1IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |