Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184168 | 0.80 | L3MBTL1 (0.36) | PKMPOLBL3MBTL1ALDH1A1BRD4 | |
| SCHEMBL14043925 | 0.74 | PKM (0.42) | PKML3MBTL1BRD4BRD2HSD17B10 | |
| SCHEMBL16200129 | 0.71 | L3MBTL1 (0.39) | L3MBTL1BRD4BRD2HSD17B10HPGD | |
| SCHEMBL18282502 | 0.71 | PKM (0.38) | PKML3MBTL1BRD4BRD2HSD17B10 | |
| SCHEMBL10274571 | 0.69 | PKM (0.46) | PKML3MBTL1BRD4BRD2HSD17B10 | |
| SCHEMBL19795212 | 0.65 | DDB1 (0.65) | PKMALDH1A1BRD4HSD17B10HPGD | |
| SCHEMBL15081338 | 0.65 | DDB1 (0.52) | PKMALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL13184318 | 0.65 | PDE1A (0.38) | PKML3MBTL1BRD4BRD2HSD17B10 | |
| SCHEMBL16698832 | 0.65 | MEN1 (0.42) | PKML3MBTL1ALDH1A1BRD4BRD2 | |
| SCHEMBL17473548 | 0.65 | HSD17B10 (0.43) | PKML3MBTL1ALDH1A1BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |