Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184154 | 0.72 | HTT (0.51) | HCAR2HTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL16200281 | 0.71 | PKM (0.42) | L3MBTL1HSD17B10LMNACNR2TSHR | |
| SCHEMBL16200329 | 0.70 | HTT (0.54) | HCAR2HTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13663859 | 0.69 | HSD17B10 (0.44) | L3MBTL1PIM1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL13184168 | 0.68 | L3MBTL1 (0.36) | L3MBTL1HSD17B10HTTLMNACNR2 | |
| SCHEMBL16200327 | 0.66 | HTT (0.39) | HCAR2HTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL14043925 | 0.65 | PKM (0.42) | L3MBTL1HSD17B10LMNACNR2BRD4 | |
| SCHEMBL3090318 | 0.65 | CNR2 (0.39) | L3MBTL1PIM1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL16200310 | 0.65 | LRRK2 (0.51) | HTTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6225573 | 0.63 | CNR2 (0.38) | L3MBTL1PIM1HSD17B10CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |