Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13066183 | 0.81 | TRPV1 (0.31) | — | |
| SCHEMBL13066184 | 0.75 | PTGS2 (0.33) | — | |
| SCHEMBL14039564 | 0.75 | MAPK8 (0.36) | KDM4E | |
| SCHEMBL13715582 | 0.74 | TRPC3 (0.33) | KDM4ERECQL | |
| SCHEMBL14039775 | 0.70 | KDM4E (0.42) | KDM4ERECQLTDP1 | |
| SCHEMBL13066243 | 0.69 | KDM4E (0.41) | KDM4ERECQLTDP1NOTUM | |
| SCHEMBL14039578 | 0.68 | P2RX7 (0.35) | KDM4ERECQLNR3C1 | |
| SCHEMBL14015667 | 0.68 | KDM4E (0.37) | KDM4ERECQLTDP1 | |
| SCHEMBL16200214 | 0.67 | ADORA2A (0.40) | KDM4ERECQL | |
| SCHEMBL13715717 | 0.66 | CYP2C9 (0.34) | KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |