Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13066184 | 0.79 | PTGS2 (0.33) | PTGS2PTGS1BRD9 | |
| SCHEMBL13184140 | 0.79 | ADORA2A (0.39) | ADORA2AADORA2BGLSALDH1A1KMT2A | |
| SCHEMBL16200218 | 0.77 | PTGS2 (0.32) | PTGS2PTGS1 | |
| SCHEMBL12440689 | 0.74 | MEN1 (0.42) | KMT2AMEN1 | |
| SCHEMBL13184160 | 0.74 | PDE2A (0.32) | PTGS2 | |
| SCHEMBL13693058 | 0.74 | ADORA2A (0.39) | ADORA2AADORA2BGLSALDH1A1KMT2A | |
| SCHEMBL21737655 | 0.74 | ADORA2A (0.44) | ADORA2AADORA2BGLSALDH1A1KMT2A | |
| SCHEMBL13180563 | 0.73 | GLS (0.61) | ADORA2AADORA2BGLSALDH1A1KMT2A | |
| SCHEMBL13715650 | 0.72 | KDM4E (0.31) | KDM4ERECQL | |
| SCHEMBL12859156 | 0.70 | GLS (0.37) | GLSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |