Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 8/20 | 0.39 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1485009 | 0.98 | RAD52 (0.37) | KDM4ERAD52CXCR4CXCL12ALDH1A1 | |
| SCHEMBL10780965 | 0.93 | — | — | |
| SCHEMBL25032534 | 0.84 | CXCR4 (0.42) | RAD52CXCR4CXCL12ALDH1A1HRH3 | |
| SCHEMBL20389859 | 0.81 | CXCR4 (0.51) | KDM4ERAD52CXCR4CXCL12HRH3 | |
| SCHEMBL6160369 | 0.77 | DPP4 (0.40) | KDM4ERAD52CXCR4CXCL12ALDH1A1 | |
| SCHEMBL3167403 | 0.77 | DPP4 (0.40) | KDM4ERAD52CXCR4CXCL12ALDH1A1 | |
| SCHEMBL1779849 | 0.77 | RAD52 (0.56) | KDM4ERAD52CXCR4CXCL12ALDH1A1 | |
| SCHEMBL455085 | 0.77 | RAD52 (0.56) | KDM4ERAD52CXCR4CXCL12ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2661264 | 0.77 | ALDH1A1 (0.37) | KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL2661266 | 0.77 | ALDH1A1 (0.37) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038479-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2015-02-05 | — | — | US | disclosed |
| US-20150038482-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2015-02-05 | — | — | US | disclosed |
| US-8927724-B2 | Isoxazole beta-lactamase inhibitors | CUBIST PHARMACEUTICALS, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| US-20140323459-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038482-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | ALPL, MGAM, PEPD | KDM4E 2756/4885RAD52 3281/4885CXCR4 1852/4885 |
| US-20150038479-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | ALPL, MGAM, PEPD | KDM4E 2756/4885RAD52 3281/4885CXCR4 1852/4885 |
| US-20140323459-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | ALPL, MGAM, PEPD | KDM4E 2756/4885RAD52 3281/4885CXCR4 1852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.