Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16201376 | 0.92 | KDM4E (0.36) | ALDH1A1HTR1DKDM4EBCHEACHE | |
| SCHEMBL16201189 | 0.90 | ALDH1A1 (0.39) | ALDH1A1HTTIL2MAP4K1HTR1D | |
| SCHEMBL16201428 | 0.85 | HRH3 (0.39) | ALDH1A1HTTL3MBTL1AXLTYRO3 | |
| SCHEMBL19432068 | 0.82 | PRMT1 (0.39) | ALDH1A1IL2MAP4K1KCNH2HRH3 | |
| SCHEMBL16201392 | 0.82 | IL2 (0.38) | ALDH1A1HTTIL2MAP4K1HTR1D | |
| SCHEMBL16201205 | 0.81 | CARM1 (0.40) | — | |
| SCHEMBL16201365 | 0.78 | HRH3 (0.42) | HRH3BCHEACHE | |
| SCHEMBL16201421 | 0.78 | MEN1 (0.36) | ALDH1A1L3MBTL1KDM4EMAPK1KMT2A | |
| SCHEMBL16201317 | 0.77 | KDM4E (0.34) | ALDH1A1KDM4EMAPK1 | |
| SCHEMBL16201347 | 0.77 | CRHR1 (0.38) | ALDH1A1HTTKDM4EKCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776972-B2 | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof | EPIZYME INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9346761-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20160137609-A1 | PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-05-19 | — | — | US | disclosed |
| US-20140323537-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323537-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | ALDH1A1 686/4885HTT 3149/4885IL2 4735/4885 |
| US-20160137609-A1 | PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | ALDH1A1 895/4885HTT 3309/4885IL2 4640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.