Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 12/20 | 1.00 |
| ▸ | LMNA | P02545 | 9/20 | 1.00 |
| ▸ | MEN1 | O00255 | 9/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 9/20 | 1.00 |
| ▸ | HTT | P42858 | 8/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.88 |
| ▸ | PTBP1 | P26599 | 2/20 | 0.88 |
| ▸ | NPC1 | O15118 | 1/20 | 0.88 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15037958 | 0.93 | NPSR1 (1.00) | NPSR1LMNAMEN1KMT2AHTT | |
| SCHEMBL16202881 | 0.92 | NPSR1 (0.94) | NPSR1LMNAMEN1KMT2AHTT | |
| SCHEMBL15037999 | 0.91 | NPSR1 (0.92) | NPSR1LMNAMEN1KMT2AHTT | |
| SCHEMBL16202856 | 0.90 | NPSR1 (0.81) | NPSR1LMNAMEN1KMT2AHTT | |
| SCHEMBL16202832 | 0.90 | NPSR1 (0.81) | NPSR1LMNAMEN1KMT2AHTT | |
| SCHEMBL15037998 | 0.90 | NPSR1 (0.82) | NPSR1LMNAMEN1KMT2AHTT | |
| SCHEMBL16202886 | 0.89 | NPSR1 (0.80) | NPSR1LMNAMEN1KMT2AHTT | |
| SCHEMBL16202882 | 0.89 | NPSR1 (0.80) | NPSR1LMNAMEN1KMT2AHTT | |
| SCHEMBL15037921 | 0.86 | NPSR1 (0.75) | NPSR1LMNAMEN1KMT2AHTT | |
| SCHEMBL15037900 | 0.86 | NPSR1 (0.75) | NPSR1LMNAMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11241436-B2 | Autophagy inducers for treatment of CNS conditions | NORTHWESTERN UNIVERSITY (US) | 2022-02-08 | — | — | US | disclosed |
| EP-2791142-B1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | US HEALTH (US) | 2019-07-03 | — | — | EP | disclosed |
| US-10301314-B2 | Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-05-28 | — | — | US | disclosed |
| US-9877966-B1 | Combination therapy for the inhibition of metastasis and tumorigenesis | OLIVA EUGENE J (US) | 2018-01-30 | — | — | US | disclosed |
| US-9877966-B1 | Combination therapy for the inhibition of metastasis and tumorigenesis | OLIVA EUGENE J (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170260192-A1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT OF HEALTH AND HUMAN SERVICES (US) | 2017-09-14 | — | — | US | disclosed |
| US-20170260192-A1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT OF HEALTH AND HUMAN SERVICES (US) | 2017-09-14 | — | — | US | disclosed |
| US-9663521-B2 | Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663521-B2 | Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-05-30 | — | — | US | disclosed |
| US-20140323438-A1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | NORTHWESTERN UNIVERSITY | 2014-10-30 | — | — | US | disclosed |
| US-20140323438-A1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | NORTHWESTERN UNIVERSITY | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323438-A1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | PGF, BRCA1, RB1 | NPSR1 907/4885LMNA 424/4885MEN1 756/4885 |
| US-20170260192-A1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | PGF, BRCA1, RB1 | NPSR1 907/4885LMNA 424/4885MEN1 756/4885 |
| US-10301314-B2 | Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis | PGF, BRCA1, RB1 | NPSR1 907/4885LMNA 424/4885MEN1 756/4885 |
| US-11241436-B2 | Autophagy inducers for treatment of CNS conditions | SQSTM1, ATG7, BECN1 | NPSR1 1165/4885LMNA 2642/4885MEN1 3544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.