Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.67 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.67 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.67 |
| ▸ | F3 | P13726 | 2/20 | 0.67 |
| ▸ | TNKS | O95271 | 1/20 | 0.67 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.67 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7060516 | 1.00 | MAPT (0.67) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL1620755 | 1.00 | MAPT (0.67) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL27737044 | 0.98 | MAPT (0.64) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL1034506 | 0.90 | MAPT (0.73) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL2153308 | 0.90 | MAPT (0.73) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL1034505 | 0.90 | MAPT (0.73) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL11560289 | 0.86 | MAPT (0.67) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL28109000 | 0.86 | MAPT (0.67) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL559826 | 0.85 | HDAC3 (0.63) | MAPTALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL559827 | 0.85 | HDAC3 (0.63) | MAPTALDH1A1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630776-B1 | FURO[2,3-B]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2023-05-17 | — | — | EP | claimed |
| US-11339174-B2 | γ-spiroketal-γ-lactones and pharmaceutical composition containing same and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-05-24 | — | — | US | claimed |
| US-20210198273-A1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-07-01 | — | — | US | claimed |
| US-10941155-B2 | Furo[2,3-b]pyran-2-one compounds and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-03-09 | — | — | US | claimed |
| US-20200165263-A1 | FURO[2,3-b]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-05-28 | — | — | US | claimed |
| EP-3630776-A1 | FURO[2,3-B]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2020-04-08 | — | — | EP | claimed |
| EP-3619214-A1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2020-03-11 | — | — | EP | claimed |
| WO-2018220647-A1 | FURO[2,3-B]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-12-06 | — | — | WO | claimed |
| WO-2018203346-A1 | γ-SPIROKETAL- γ –LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-11-08 | — | — | WO | claimed |
| EP-0380689-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE 2-HYDROXY-4-PHENYL-3-BUTENOIC ACID | DAICEL CHEM (JP) | 1995-10-04 | — | — | EP | claimed |
| US-5429935-A | Reduction of the corresponding ketone with microorganisms | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1995-07-04 | — | — | US | claimed |
| US-5288620-A | Reducing 2-oxo-4-phenyl-3-butenoic acid with enzyme preparation derived from microorganisms | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1994-02-22 | — | — | US | claimed |
| US-5194380-A | Treatment with a microorganism | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1993-03-16 | — | — | US | claimed |
| EP-0380689-A1 | PROCESS FOR PREPARING OPTICALLY ACTIVE 2-HYDROXY-4-PHENYL-3-BUTENOIC ACID | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-08 | — | — | EP | claimed |
| JP-2100688-A | — | — | None | — | — | JP | disclosed |
| JP-6197774-A | — | — | None | — | — | JP | disclosed |
| JP-3074346-A | — | — | None | — | — | JP | disclosed |
| JP-H00223876-A | — | — | 0001-01-01 | — | — | JP | disclosed |
| JP-H00223875-A | — | — | 0001-01-01 | — | — | JP | disclosed |
| JP-H00380090-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10941155-B2 | Furo[2,3-b]pyran-2-one compounds and process for preparation thereof | KMO, ALDOA, AKR1C2 | MAPT 4627/4885ALDH1A1 52/4885HDAC3 1508/4885 |
| US-11339174-B2 | γ-spiroketal-γ-lactones and pharmaceutical composition containing same and process for preparation thereof | HSD17B7, PKD1, CYP17A1 | MAPT 1884/4885ALDH1A1 420/4885HDAC3 612/4885 |
| US-20200165263-A1 | FURO[2,3-b]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | KMO, ALDOA, AKR1C2 | MAPT 4627/4885ALDH1A1 52/4885HDAC3 1508/4885 |
| US-20210198273-A1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | HSD17B7, PKD1, CYP17A1 | MAPT 1946/4885ALDH1A1 377/4885HDAC3 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.