Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.67 |
| ▸ | CCR3 | P51677 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.51 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.51 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.51 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16197679 | 0.99 | SIGMAR1 (0.66) | SIGMAR1CCR3HTR2AHTR2CCARM1 | |
| SCHEMBL16208337 | 0.82 | SIGMAR1 (0.65) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL16208531 | 0.80 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL16208335 | 0.79 | HTR2A (0.66) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL16197437 | 0.79 | SIGMAR1 (0.65) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL16208332 | 0.79 | SIGMAR1 (0.65) | SIGMAR1HTR2AHTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL17583768 | 0.79 | SIGMAR1 (0.98) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL16198004 | 0.78 | SIGMAR1 (0.64) | SIGMAR1HTR2AHTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL16197598 | 0.78 | HTR2A (0.64) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL16197432 | 0.78 | HTR1A (0.58) | SIGMAR1HTR2AHTR2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2989105-B1 | PYRAZINO[1,2-A]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS SA (ES) | 2020-03-11 | — | — | EP | claimed |
| US-9879015-B2 | Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-01-30 | — | — | US | disclosed |
| US-9879015-B2 | Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-01-30 | — | — | US | disclosed |
| US-20160060268-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2016-03-03 | — | — | US | disclosed |
| US-20160060268-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2016-03-03 | — | — | US | disclosed |
| WO-2014173903-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060268-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | IDO1, TPH1, IDO2 | SIGMAR1 168/4885CCR3 3485/4885HTR2A 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.