Sugi Predict

Sugi Predict / Compounds / SCHEMBL16211787

SCHEMBL16211787

SCHEMBL16211787

CC(C)(C)[Si](OC1CC2C(C1)C2C(=O)O)(c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ BACE1 P56817 1/20 0.35
▸ POLB P06746 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.31
▸ PKM P14618 1/20 0.31
▸ FABP7 O15540 2/20 0.31
▸ FABP5 Q01469 2/20 0.31
▸ SSTR4 P31391 1/20 0.31
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30
▸ CHRM3 P20309 1/20 0.30
▸ CYP3A4 P08684 1/20 0.30
▸ HTT P42858 1/20 0.30
▸ SMN1; SMN2 Q16637 1/20 0.30
▸ SMYD2 Q9NRG4 1/20 0.30
▸ EDNRB P24530 1/20 0.30
▸ EDNRA P25101 1/20 0.30
▸ ABL1 P00519 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19896122 1.00 BACE1 (0.35) BACE1POLBALDH1A1PKMFABP7
SCHEMBL19896128 1.00 BACE1 (0.35) BACE1POLBALDH1A1PKMFABP7
SCHEMBL19896125 1.00 BACE1 (0.35) BACE1POLBALDH1A1PKMFABP7
SCHEMBL30936052 1.00 BACE1 (0.35) BACE1POLBALDH1A1PKMFABP7
SCHEMBL23549599 0.90 BACE1 (0.35) BACE1SSTR4SMYD2
SCHEMBL16821551 0.90 BACE1 (0.35) BACE1SSTR4SMYD2
SCHEMBL22194922 0.89 BACE1 (0.34) BACE1KMT2A
SCHEMBL22194926 0.89 BACE1 (0.34) BACE1KMT2A
SCHEMBL22194924 0.89 BACE1 (0.34) BACE1KMT2A
SCHEMBL30107195 0.89 BACE1 (0.34) BACE1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117024411-B Isoquinoline as HPK1 inhibitor 豪夫迈·罗氏有限公司 2026-05-19 — — CN disclosed
US-20260008775-A1 AZOLE MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION CONVELO THERAPEUTICS, INC. 2026-01-08 — — US disclosed
EP-2991978-B1 BIHETEROARYL COMPOUNDS AND USES THEREOF F HOFFMANN LA ROCHE SA (CH) 2025-08-20 — — EP disclosed
EP-4594309-A1 AZOLE MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION Genentech Inc. (US) 2025-08-06 — — EP disclosed
WO-2025133989-A1 SMYD MODULATORS AND USES THEREOF ALT-BIO PTE. LTD. (SG) 2025-06-26 — — WO disclosed
US-20240391930-A1 SPIROCYCLIC BICYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION GENENTECH, INC. 2024-11-28 — — US disclosed
EP-4436974-A1 SPIROCYCLIC BICYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION Genentech, Inc. (US) 2024-10-02 — — EP disclosed
WO-2024073662-A1 AZOLE MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION GENENTECH, INC. (US) 2024-04-04 — — WO disclosed
EP-3601284-B1 NAPHTHYRIDINES AS INHIBITORS OF HPK1 HOFFMANN LA ROCHE (CH) 2023-12-27 — — EP disclosed
WO-2023097230-A1 SPIROCYCLIC BICYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION GENENTECH, INC. (US) 2023-06-01 — — WO disclosed
US-10010549-B2 Biheteroaryl compounds and uses thereof GENENTECH, INC. (US) 2018-07-03 — — US disclosed
US-20180133219-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2018-05-17 — — US disclosed
EP-3083599-A1 PYRAZOLE DERIVATIVES AND USES THEREOF AS INHIBITORS OF DLK F. Hoffmann-La Roche AG (CH) 2016-10-26 — — EP disclosed
US-9365583-B2 Substituted pyrazoles and uses thereof GENENTECH, INC. (US) 2016-06-14 — — US disclosed
EP-2991978-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF F. Hoffmann-La Roche SA (CH) 2016-03-09 — — EP disclosed
US-20160052940-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2016-02-25 — — US disclosed
WO-2015091889-A1 PYRAZOLE DERIVATIVES AND USES THEREOF AS INHIBITORS OF DLK F. HOFFMANN-LA ROCHE AG (CH) 2015-06-25 — — WO disclosed
US-20150175619-A1 SUBSTITUTED PYRAZOLES AND USES THEREOF GENENTECH, INC. (US) 2015-06-25 — — US disclosed
WO-2014177060-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF F.HOFFMANN-LA ROCHE AG (CH) 2014-11-06 — — WO disclosed
WO-2014177060-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF F.HOFFMANN-LA ROCHE AG (CH) 2014-11-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10010549-B2 Biheteroaryl compounds and uses thereof BCHE, SNCA, HAX1 BACE1 11/4885POLB 3984/4885ALDH1A1 950/4885
US-20240391930-A1 SPIROCYCLIC BICYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION MAG, SGMS1, PMP22 BACE1 951/4885POLB 3065/4885ALDH1A1 2143/4885
US-20150175619-A1 SUBSTITUTED PYRAZOLES AND USES THEREOF PDXK, NLK, PDK3 BACE1 100/4885POLB 2232/4885ALDH1A1 635/4885
US-20180133219-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, HAX1 BACE1 11/4885POLB 3984/4885ALDH1A1 950/4885
US-20160052940-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, HAX1 BACE1 11/4885POLB 3984/4885ALDH1A1 950/4885
US-20260008775-A1 AZOLE MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION MAG, NR1H3, NR1H2 BACE1 1808/4885POLB 3410/4885ALDH1A1 2459/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.