Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870114 | 1.00 | ALDH1A1 (0.53) | ALDH1A1PKMPTGS1PTGS2GAA | |
| SCHEMBL10421278 | 0.85 | ALDH1A1 (0.54) | ALDH1A1PKMGAAHPGDKDM4E | |
| SCHEMBL4429188 | 0.83 | ALDH1A1 (0.50) | ALDH1A1PKMPTGS1PTGS2HPGD | |
| SCHEMBL502079 | 0.80 | PTGS1 (0.47) | ALDH1A1PKMPTGS1PTGS2HPGD | |
| SCHEMBL4738905 | 0.79 | PTGS1 (0.50) | ALDH1A1PKMPTGS1PTGS2HPGD | |
| SCHEMBL5162325 | 0.76 | ALDH1A1 (0.56) | ALDH1A1PKMPTGS1PTGS2GAA | |
| SCHEMBL21620435 | 0.75 | MGLL (0.53) | ALDH1A1PKMPTGS1PTGS2HPGD | |
| SCHEMBL31005834 | 0.75 | MGLL (0.53) | ALDH1A1PKMPTGS1PTGS2HPGD | |
| SCHEMBL3505155 | 0.74 | ALDH1A1 (0.58) | ALDH1A1PKMGAAHPGDKDM4E | |
| SCHEMBL24300565 | 0.72 | ALDH1A1 (0.56) | ALDH1A1PKMGAAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2992008-A1 | THERAPEUTIC PEPTIDES | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2016-03-09 | — | — | EP | disclosed |
| WO-2014178018-A1 | THERAPEUTIC PEPTIDES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-11-06 | — | — | WO | disclosed |