Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666468 | 0.90 | GAA (0.42) | TSHRGAAPKMBACE1HPGD | |
| SCHEMBL1812580 | 0.80 | OPRK1 (0.48) | TSHRLMNACYP2D6GAAKMT2A | |
| SCHEMBL1665969 | 0.77 | TSHR (0.39) | TSHRLMNACHRM2ADRA2ACYP2D6 | |
| SCHEMBL6120052 | 0.76 | SMN1; SMN2 (0.46) | TSHRLMNAGAAKMT2APKM | |
| SCHEMBL23871646 | 0.75 | ALDH1A1 (0.52) | TSHRGAAALDH1A1 | |
| SCHEMBL23857529 | 0.75 | ALDH1A1 (0.52) | TSHRGAAALDH1A1 | |
| SCHEMBL11982109 | 0.75 | LMNA (0.44) | TSHRLMNACHRM2ADRA2ACYP2D6 | |
| SCHEMBL15457715 | 0.75 | SLC6A2 (0.45) | TSHRLMNAGAAKMT2APKM | |
| SCHEMBL3617827 | 0.75 | SLC6A2 (0.45) | TSHRLMNAGAAKMT2APKM | |
| SCHEMBL30148934 | 0.75 | ALDH1A1 (0.46) | TSHRGAAKMT2APKMBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221819-B2 | Spirocyclic compounds as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-12-29 | — | — | US | disclosed |
| US-8877749-B2 | Spirocyclic compounds as modulators of chemokine receptor activity | Bristol-Myers Squibbs Company (US) | 2014-11-04 | — | — | US | disclosed |