Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496138 | 0.89 | GRM4 (0.45) | MAPTRAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL21313228 | 0.84 | TLR8 (0.46) | MAPTRAB9ANPC1ADORA2AMAOB | |
| SCHEMBL21313270 | 0.84 | MAPT (0.38) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL12495825 | 0.84 | ADK (0.51) | ADKMAPTRAB9ANPC1ADORA2A | |
| SCHEMBL21313154 | 0.84 | ADORA2A (0.46) | MAPTRAB9ANPC1ADORA2AALDH1A1 | |
| SCHEMBL16223029 | 0.83 | MAOB (0.41) | MAPTRAB9ANPC1ADORA2AMAOB | |
| SCHEMBL21313146 | 0.83 | ADORA2A (0.44) | MAPTRAB9ANPC1ADORA2AMAOB | |
| SCHEMBL21313196 | 0.81 | ADORA2A (0.44) | MAPTRAB9ANPC1ADORA2AHPGD | |
| SCHEMBL12495884 | 0.81 | HDAC3 (0.41) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL21313237 | 0.81 | ADORA2A (0.42) | MAPTRAB9ANPC1ADORA2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3195867-B1 | PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR V V I (CZ) | 2019-09-04 | — | — | EP | claimed |
| US-8883798-B2 | Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, v.v.i. (CZ) | 2014-11-11 | — | — | US | claimed |