Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16223159 | 0.99 | KMT2A (0.51) | KMT2ANAMPTALDH1A1GAAGFER | |
| SCHEMBL16223204 | 0.96 | RAB9A (0.43) | KMT2ANAMPTALDH1A1GAAGFER | |
| SCHEMBL16223222 | 0.80 | RECQL (0.57) | KMT2AALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL16229912 | 0.79 | MAPT (0.46) | KMT2AALDH1A1GAANPC1RAB9A | |
| SCHEMBL16223221 | 0.78 | MEN1 (0.53) | KMT2ANAMPTALDH1A1GAAHPGD | |
| SCHEMBL16223199 | 0.76 | HPGD (0.48) | KMT2AALDH1A1GAANPC1RAB9A | |
| SCHEMBL16223209 | 0.74 | MAPT (0.47) | KMT2ANAMPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16223594 | 0.74 | ITGA4 (0.53) | KMT2AALDH1A1GAANPC1RAB9A | |
| SCHEMBL16223180 | 0.73 | NPC1 (0.58) | KMT2ANAMPTALDH1A1GAANPC1 | |
| SCHEMBL16223194 | 0.73 | MAPT (0.50) | KMT2AALDH1A1GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2801573-A1 | Hydantoine derivatives as CD38 inhibitors | SANOFI (FR) | 2014-11-12 | — | — | EP | claimed |
| WO-2014180544-A1 | HYDANTOINE DERIVATIVES AS CD38 INHIBITORS | SANOFI (FR) | 2014-11-13 | — | — | WO | disclosed |
| WO-2014180544-A1 | HYDANTOINE DERIVATIVES AS CD38 INHIBITORS | SANOFI (FR) | 2014-11-13 | — | — | WO | disclosed |
| EP-2801573-A1 | Hydantoine derivatives as CD38 inhibitors | SANOFI (FR) | 2014-11-12 | — | — | EP | disclosed |
| EP-2801573-A1 | Hydantoine derivatives as CD38 inhibitors | SANOFI (FR) | 2014-11-12 | — | — | EP | disclosed |