SCHEMBL162277

SCHEMBL162277

O=C=Nc1ccc(Cl)cc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
THRB P10828 1/20 0.37
KDM4E B2RXH2 2/20 0.36
TDP1 Q9NUW8 2/20 0.35
MAPK1 P28482 1/20 0.35
CYP3A4 P08684 3/20 0.35
ALDH1A1 P00352 2/20 0.35
HPGD P15428 2/20 0.35
HCAR1 Q9BXC0 1/20 0.34
POLQ O75417 1/20 0.34
PKM P14618 1/20 0.34
TP53 P04637 1/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HTT P42858 2/20 0.33
GAA P10253 2/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29648862 1.00 RAB9A (0.40) RAB9ACYP1A2CYP2D6CYP2C19THRB
SCHEMBL8593598 0.87 MAPK1 (0.47) RAB9ACYP1A2CYP2D6CYP2C19KDM4E
SCHEMBL7525499 0.87 ALDH1A1 (0.54) RAB9ACYP1A2CYP2D6CYP2C19THRB
SCHEMBL10886564 0.84 CYP3A4 (0.44) TDP1MAPK1CYP3A4ALDH1A1HPGD
SCHEMBL7704445 0.83 CYP3A4 (0.32) RAB9ACYP1A2CYP2D6CYP2C19THRB
SCHEMBL3665786 0.82 RAB9A (0.36) RAB9ACYP1A2CYP2D6CYP2C19THRB
SCHEMBL30562945 0.82 RAB9A (0.36) RAB9ACYP1A2CYP2D6CYP2C19THRB
SCHEMBL9235250 0.81 CYP3A4 (0.49) TDP1CYP3A4ALDH1A1HPGDTRPA1
SCHEMBL3104369 0.80 CYP3A4 (0.50) CYP1A2TDP1MAPK1CYP3A4ALDH1A1
SCHEMBL31135862 0.80 CES2 (0.46) CYP1A2CYP2C19KDM4ETDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115386245-A Preparation method and application of lipophilic carbon nitride nanosheet 浙江理工大学 2022-11-25 CN claimed
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 EP claimed
EP-0129214-B1 METHOD FOR THE PREPARATION OF BENZENAMINES OCCIDENTAL CHEMICAL CORPORATION (US) 1986-10-29 EP claimed
EP-0129214-A1 Method for the preparation of benzenamines OCCIDENTAL CHEMICAL CORPORATION (US) 1984-12-27 EP claimed
US-4481370-A REACTING HYDROGEN FLUORIDE WITH A PHENYL CARBAMIC FLUORIDE OCCIDENTAL CHEMICAL CORPORATION (US) 1984-11-06 US claimed
EP-4713378-A1 ESTERIFIED ETHANOLAMINES FOR PREPARING ISOCYANURATE POLYMERS Covestro Deutschland AG (DE) 2026-03-25 EP disclosed
EP-3774961-B1 ADDUCTS OF AMINE CATALYSTS FOR PRODUCING ISOCYANURATE POLYMERS COVESTRO DEUTSCHLAND AG (DE) 2025-01-15 EP disclosed
WO-2024236000-A1 ESTERIFIED ETHANOLAMINES FOR PREPARING ISOCYANURATE POLYMERS COVESTRO DEUTSCHLAND AG (DE) 2024-11-21 WO disclosed
WO-2024237266-A1 MELANOCORTIN 2-TYPE RECEPTOR ANTAGONIST 株式会社スコヒアファーマ 2024-11-21 WO disclosed
EP-4464727-A1 ESTERIFIED ETHANOLAMINES FOR THE PREPARATION OF ISOCYANURATE POLYMERS Covestro Deutschland AG (DE) 2024-11-20 EP disclosed
US-20240150515-A1 Low Viscosity Catalyst Compositions for Producing Isocyanurate Polymers COVESTRO DEUTSCHLAND AG (DE) 2024-05-09 US disclosed
EP-4298140-A1 LOW VISCOSITY CATALYST COMPOSITIONS FOR PRODUCING ISOCYANURATE POLYMERS Covestro Deutschland AG (DE) 2024-01-03 EP disclosed
EP-0015110-B1 ANTICOCCIDIAL COMPOSITION, CARBANILIDES AND METHOD OF PREPARING THEM ELI LILLY AND COMPANY (US) 1985-08-21 EP disclosed
US-4526997-A Amino, nitro, fluoro substituted carbanilides DOHERTY GEORGE O P O 1985-07-02 US disclosed
EP-0129214-A1 Method for the preparation of benzenamines OCCIDENTAL CHEMICAL CORPORATION (US) 1984-12-27 EP disclosed
US-4481370-A REACTING HYDROGEN FLUORIDE WITH A PHENYL CARBAMIC FLUORIDE OCCIDENTAL CHEMICAL CORPORATION (US) 1984-11-06 US disclosed
US-4468380-A Anticoccidial combinations comprising polyether antibiotics and carbanilides ELI LILLY AND COMPANY (US) 1984-08-28 US disclosed
US-4405623-A HYPOTENSIVE AGENTS, VASODILATORS MASAYUKI ISHIKAWA (JP) 1983-09-20 US disclosed
EP-0040793-A1 Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof Ishikawa, Masayuki (JP) 1981-12-02 EP disclosed
EP-0015110-A2 Anticoccidial composition, carbanilides and method of preparing them ELI LILLY AND COMPANY (US) 1980-09-03 EP disclosed