Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229360 | 0.80 | GCGR (0.36) | TYMPL3MBTL1ALDH1A1TLR8TLR7 | |
| SCHEMBL11862558 | 0.79 | TYMP (0.38) | TYMPL3MBTL1ALDH1A1TLR8TLR7 | |
| SCHEMBL12495762 | 0.79 | PDK2 (0.42) | TYMPL3MBTL1ALDH1A1TLR8TLR7 | |
| SCHEMBL12495812 | 0.76 | L3MBTL1 (0.40) | TYMPL3MBTL1ALDH1A1HPGDHTT | |
| SCHEMBL12496378 | 0.75 | HPGD (0.41) | TYMPL3MBTL1ALDH1A1TLR8TLR7 | |
| SCHEMBL12496379 | 0.75 | TLR8 (0.47) | TYMPTLR8TLR7HPGDNPSR1 | |
| SCHEMBL18097936 | 0.73 | PDE10A (0.39) | ALDH1A1MAPTTDP1 | |
| SCHEMBL9739003 | 0.73 | TLR8 (0.36) | TYMPALDH1A1TLR8TLR7HTT | |
| SCHEMBL5158467 | 0.72 | PDE10A (0.35) | TYMPL3MBTL1ALDH1A1PDK2KMT2A | |
| SCHEMBL12496096 | 0.72 | CYP1A2 (0.39) | TYMPL3MBTL1ALDH1A1TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883798-B2 | Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, v.v.i. (CZ) | 2014-11-11 | — | — | US | disclosed |