Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 13/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229752 | 0.92 | SLC6A9 (0.52) | SLC6A9HTR1AHTR7KCNH2SLC8A1 | |
| SCHEMBL16784630 | 0.91 | SLC6A9 (0.54) | SLC6A9HTR1AHTR7KCNH2 | |
| SCHEMBL16784632 | 0.91 | SLC6A9 (0.52) | SLC6A9HTR1AHTR7KCNH2HTR6 | |
| SCHEMBL16229753 | 0.90 | SLC6A9 (0.41) | SLC6A9HTR1AHTR7DGAT1MGAT3 | |
| SCHEMBL16229789 | 0.88 | DGAT1 (0.40) | SLC6A9DGAT1MGAT3MGAT2 | |
| SCHEMBL16229749 | 0.87 | SLC6A9 (0.55) | SLC6A9KCNH2 | |
| SCHEMBL16784654 | 0.86 | POLB (0.40) | SLC6A9HTR1AHTR7SLC8A1ALK | |
| SCHEMBL16229806 | 0.84 | DGAT1 (0.35) | SLC6A9DGAT1MGAT3MGAT2HTR6 | |
| SCHEMBL16784626 | 0.83 | SLC6A9 (0.50) | SLC6A9HTR1AHTR7KCNH2DRD2 | |
| SCHEMBL16784639 | 0.83 | SLC6A9 (0.45) | SLC6A9HTR1AHTR7KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |