Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16230015 | 0.80 | L3MBTL1 (0.40) | LMNANPC1RAB9AEGFRCDK2 | |
| SCHEMBL16230012 | 0.74 | EGFR (0.37) | LMNARAB9ACNR1EGFRCDK2 | |
| SCHEMBL10316151 | 0.73 | SMO (0.52) | NPC1RAB9AATMCNR1CNR2 | |
| SCHEMBL13708874 | 0.69 | LMNA (0.46) | LMNARAB9AMEN1GAAKMT2A | |
| SCHEMBL621869 | 0.64 | POLB (0.71) | LMNANPC1RAB9AATMCNR1 | |
| SCHEMBL7847521 | 0.62 | LMNA (0.41) | LMNANPC1RAB9AMEN1GAA | |
| SCHEMBL27836537 | 0.62 | LMNA (0.57) | LMNANPC1RAB9AATMMEN1 | |
| SCHEMBL10314639 | 0.61 | LMNA (0.56) | LMNANPC1RAB9AMEN1GAA | |
| SCHEMBL12962930 | 0.61 | LMNA (0.43) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL13708880 | 0.61 | LMNA (0.53) | LMNANPC1RAB9AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471791-B1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2014-11-12 | — | — | EP | disclosed |