Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | USP1 | O94782 | 2/20 | 0.34 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.34 |
| ▸ | GCG | P01275 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL906025 | 1.00 | GRM5 (0.36) | GRM5LMNASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL28721300 | 0.77 | CRHR1 (0.46) | LMNAKDM4EUSP1WDR48P2RX3 | |
| SCHEMBL29608562 | 0.77 | CRHR1 (0.46) | LMNAKDM4EUSP1WDR48P2RX3 | |
| SCHEMBL12107186 | 0.74 | PDE4D (0.43) | SMN1; SMN2KDM4EGAAUSP1WDR48 | |
| SCHEMBL14670409 | 0.74 | EGFR (0.43) | SMN1; SMN2CYP19A1P2RX3CFTRGOPC | |
| SCHEMBL906176 | 0.74 | CSF1R (0.46) | KDM4ECYP19A1CFTRGOPCKCNN4 | |
| SCHEMBL28763820 | 0.74 | CSF1R (0.46) | KDM4ECYP19A1CFTRGOPCKCNN4 | |
| SCHEMBL14670663 | 0.74 | USP1 (0.51) | LMNASMN1; SMN2USP1WDR48P2RX3 | |
| SCHEMBL14670585 | 0.74 | USP1 (0.51) | LMNASMN1; SMN2USP1WDR48P2RX3 | |
| SCHEMBL30930030 | 0.74 | USP1 (0.51) | LMNASMN1; SMN2USP1WDR48P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2277865-B1 | Phenyl-substituted 6-ring nitrogen-heterocycles as microtubule polymerisation inhibitors | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2014-11-12 | — | — | EP | disclosed |
| CN-102127056-B | Tubulin inhibitors | YM BIOSCIENCES AUSTRALIA PTY | 2013-08-21 | — | — | CN | disclosed |
| CN-1890218-B | Tubulin inhibitors | CYTOPIA RES PTY LTD | 2011-08-03 | — | — | CN | disclosed |
| CN-102127056-A | Tubulin inhibitors | CYTOPIA RES PTY LTD | 2011-07-20 | — | — | CN | disclosed |
| CN-1890218-A | Tubulin inhibitors | CYTOPIA RES PTY LTD (AU) | 2007-01-03 | — | — | CN | disclosed |