Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 3/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | S100A9 | P06702 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235792 | 0.83 | CCR4 (0.49) | CCR4PDCD1CD274MAPK1S100A9 | |
| SCHEMBL16235505 | 0.80 | CCR4 (0.70) | CCR4S100A9ACLY | |
| SCHEMBL16235231 | 0.77 | RAB9A (0.40) | CCR4MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL16235390 | 0.73 | GAA (0.41) | CCR4MAPK1S100A9GAARAB9A | |
| SCHEMBL16235141 | 0.73 | CCR4 (0.50) | CCR4PDCD1CD274MEN1KMT2A | |
| SCHEMBL16235235 | 0.72 | TP53 (0.41) | CCR4MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL16234928 | 0.72 | LMNA (0.39) | CCR4KMT2AALDH1A1MAPK1NPC1 | |
| SCHEMBL16235436 | 0.71 | GAA (0.38) | CCR4KMT2AALDH1A1MAPK1S100A9 | |
| SCHEMBL16235107 | 0.70 | TP53 (0.39) | CCR4MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL16235503 | 0.70 | S100A9 (0.52) | CCR4S100A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |