Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 4/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 7/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.43 |
| ▸ | S100A9 | P06702 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235650 | 0.83 | S100A9 (0.39) | CCR4S100A9TP53ACLYLMNA | |
| SCHEMBL16235350 | 0.83 | CCR4 (0.46) | CCR4PDCD1CD274S100A9GAA | |
| SCHEMBL16235141 | 0.80 | CCR4 (0.50) | CCR4PDCD1CD274GAATP53 | |
| SCHEMBL16235497 | 0.80 | CCR4 (0.76) | CCR4S100A9 | |
| SCHEMBL16235440 | 0.76 | RAB9A (0.40) | CCR4S100A9GAATP53ACLY | |
| SCHEMBL16235390 | 0.74 | GAA (0.41) | CCR4S100A9GAATP53ACLY | |
| SCHEMBL16235464 | 0.73 | S100A9 (0.52) | CCR4S100A9TP53ACLY | |
| SCHEMBL16235235 | 0.73 | TP53 (0.41) | CCR4GAATP53ACLYLMNA | |
| SCHEMBL16234928 | 0.73 | LMNA (0.39) | CCR4GAATP53ACLYLMNA | |
| SCHEMBL16235298 | 0.72 | FABP4 (0.41) | CCR4S100A9ACLYLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |