Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16234966 | 0.84 | GLA (0.44) | TP53ALDH1A1LMNAGLAGAA | |
| SCHEMBL16235080 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2TP53ALDH1A1USP2MAPK1 | |
| SCHEMBL16235440 | 0.80 | RAB9A (0.40) | SMN1; SMN2TP53MAPK1LMNAHTT | |
| SCHEMBL6367173 | 0.73 | SMN1; SMN2 (0.61) | SMN1; SMN2TP53ALDH1A1MAPK1LMNA | |
| SCHEMBL16234972 | 0.70 | RAB9A (0.40) | SMN1; SMN2TP53ALDH1A1MAPK1LMNA | |
| SCHEMBL16235759 | 0.68 | TSHR (0.50) | SMN1; SMN2ALDH1A1MAPK1LMNAHTT | |
| SCHEMBL6554769 | 0.68 | ALDH1A1 (0.53) | ALDH1A1LMNAGAACYP1A2CYP2C19 | |
| SCHEMBL29131021 | 0.67 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1MAPK1LMNAGLA | |
| SCHEMBL30602406 | 0.67 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1MAPK1LMNAGLA | |
| SCHEMBL5891884 | 0.66 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53ALDH1A1LMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |